Effect of buckwheat on high-fat diet rat lipid metabolism
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摘要: 研究了荞麦粉(buckwheat,BW)对高脂膳食大鼠体内抗氧化活性的影响。将50只成年Wistar雄性大鼠随机分为基础对照组、高脂模型对照组、荞麦粉低、中、高剂量组(1、5、10g/kg·d),喂养30d后,测定血清中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)的活性及丙二醛(MDA)的含量和肝脏组织中超氧化物歧化酶(SOD)活性及丙二醛(MDA)的含量;并观察主动脉结构。结果显示,荞麦粉中、高剂量组与模型对照组相比,荞麦粉可使高脂膳食大鼠血清SOD、GSH-PX的活性增强(p<0.05)及MDA的含量显著减少(p<0.05);可使肝脏中SOD活性显著增强(p<0.05),但MDA的含量显著减少(p<0.05);主动脉光镜结构显示荞麦粉对高脂膳食大鼠肝脏具有保护作用。说明荞麦粉具有调节高脂膳食大鼠抗氧化的能力。Abstract: The aim of this study was to point out the effect of buckwheat on antioxidant activity of hyperlipidemia rats. Fifty male Wistar hamsters were assigned randomly to the following groups:control diet,high-fat diet(HFD)and low,medium,high dosage BW(1,5,10g/kg·d) groups. The SOD,GSH-PX and MDA in serum and SOD,MDA in livers were detected after 30 days. The results showed that compared with model group,the levels of SOD,GSH-PX were increased(p<0.05),MDA was decreased(p<0.05) in serum,the buckwheat group SOD was increased(p<0.05),MDA was decreased(p<0.05) in liver of buckwheat group. Buckwheat may improve the antioxidant activity of high-fat diet-induced rats.
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