Effect of polysaccharides extract from Codonopisis pilosula on glycemia and lipidemia in alloxan-induced diabetic rats
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摘要: 研究纹党多糖(Codonopisis pilosula polysaccharide,CPP)对四氧嘧啶诱导糖尿病大鼠血糖和血脂的影响。以腹腔注射四氧嘧啶(ALX)构建大鼠糖尿病模型,将建模成功的大鼠随机分为糖尿病模型组、CPP高、中、低剂量处理组、阳性对照组(二甲双胍处理组、格列苯脲处理组和肾上腺素处理组),以生理盐水为空白对照组。连续灌胃给药28 d,研究CPP对糖尿病大鼠空腹血糖(FBG)、糖化血红蛋白(Hb Alc)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)等指标的影响。结果显示,CPP能明显降低正常大鼠血糖,能极显著(p<0.01)降低肾上腺素引起的高血糖,能够有效降低糖尿病大鼠的FBG、Hb Alc、TC、TG,升高HDL含量。纹党多糖能够显著降低糖尿病大鼠血糖并显著改善糖尿病大鼠血脂代谢紊乱。Abstract: The effects of polysaccharides from Codonopisis pilosula on glycemia and lipidemia in alloxan-induced diabetic rats were investigated in this study. The Sprague-Dawley rats were randomly divided into six groups:blank control group,positive control group(metformin group,glibenclamide group,epinephrine group),diabetic model group, and CPP- treated groups( low-, medium-, and high- dosage). The CPP was continuous intragastric administration of polysaccharide 28 d, to investigated the effects of polysaccharides on blood glucose(FBG),glycosylated hemoglobin(Hb Alc),total cholesterol(TC) triglyceride(TG),high density lipoprotein( HDL) and low density liporotein( LDL) in alloxan-induced diabetic rats. The results showed that the CPP could significantly( p < 0. 01) reduced blood glucose in normal rats, could significantly reduced adrenaline induced hyperglycemia, could reduced the levels of FBG, Hb Alc, TC and TG in serum in alloxan-induced diabetic rats,and increased the concentrations of HDL significantly. In summary,CPP had effects on decreasing the blood glucose and adjusting the disorder of lipid metabolism in alloxan-induced diabetic rats.
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Keywords:
- Codonopisis pilosula /
- polysaccharides /
- diabetes rats /
- hypoglycemia /
- blood lipid
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