Effects of okra extract on blood glucose and lipids in type 2 diabetes mellitus rats
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摘要: 目的:探索黄秋葵水提物对2型糖尿病大鼠糖、脂代谢的影响。方法:将雄性SD大鼠按体重随机分为正常对照组和实验组,分别饲以普通饲料和高糖高脂饲料。4周后,实验组大鼠腹腔注射链脲佐菌素（STZ）建立2型糖尿病模型,之后按血糖随机分为模型组、阳性对照组（0.64 g/kg降糖宁混悬液灌胃）、黄秋葵水提物高、中、低剂量组（分别以2.60、1.56、0.78 g/kg黄秋葵冻干粉添加到饲料中）,持续4周。记录大鼠体重、摄食量、饮水量、尿量,检测空腹血糖及总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）。结果:黄秋葵高剂量组血糖低于模型组和低剂量组（p<0.05,p<0.05）;黄秋葵各剂量组的TC值显著低于模型组（p<0.01）;高剂量组LDL-C低于模型组（p<0.01）。结论:黄秋葵水提物能显著降低2型糖尿病大鼠的血糖和血脂水平。Abstract: Objective: To explore the effects of the aqueous extract of okra on the blood glucose and lipid profiles in type 2 diabetes mellitus( T2DM) rats.Methods: The male SD rats were randomly divided into normal control group and experimental groups according to the body weight.The rats in the two groups were fed with lab chow and high- sugar and high- fat diet respectively. After four weeks of feeding,the rats in the experimental group received peritoneal injection of streptozotocin( STZ). Based on the glucose level,the succeed model rats were randomly re- grouped as blank control,positive control( Jiangtangning gavage,0.64 g / kg),high,middle,and low dose of okra extract groups( the okra extract was added into the high fat diet at the dosages of 2.60 g / kg,1.56 g / kg,and0.78 g / kg respectively).The experiment lasted for four weeks.Body weight,average levels of food and water,and blood glucose level were measured weekly.At the end of experiment,the blood samples of the rats were collected and analyzed for serum glucose,triglyceride( TG),total cholesterol( TC),high density lipoprotein cholesterol( HDL-C),and low density lipoprotein cholesterol( LDL- C).Results: The serum glucose was lower in the rats of high dose group than that in blank control group and low does group( p < 0.05,p < 0.05).Serum TC was lower in all okra feeding groups of rats than those in blank control group( p < 0.01).Serum LDL- C level was lower in high dose group rats than that in blank control group( p < 0.01). Conclusion: The aqueous extract of okra can markedly decline serum glucose and lipid in T2 DM rats.
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Keywords:
- The aqueous extract of okra /
- SD rats /
- type 2 diabetes /
- blood glucose /
- serum lipids
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