Research progress on prevention and treatment of T2DM with apigenin
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摘要: 本文拟整合目前关于芹菜素用于预防和治疗2型糖尿病(type 2 diabetes mellitus,T2DM)和肥胖的研究成果,重点强调芹菜素可作用于β细胞、脂肪细胞、肝细胞以及骨骼肌细胞上的各种分子靶点,调节不同的信号转导,而保护β细胞功能和改善外周组织胰岛素敏感性,对进一步开发芹菜素衍生的一些功能性食物作为糖尿病的替代疗法具有指导意义。同时讨论芹菜素药理作用研究中存在的争议,以及后续研究中需要加强的方面。Abstract: This review attempts to integrate the current knowledge about apigenin for potential to treat and prevent diabetes and obesity, also the mechanisms coupling signaling pathways manipulated by apigenin to improve β-cells function and insulin sensitive involving of the multitude of cell signaling pathways in pancreas, liver, skeletal muscle or adipose tissues were emphasized on. Apigenin shows great promise, which implies that apigenin derived from functional foods offer a novel and important approach for prevention of obesity and diabetes.The controversies and uncertainties in the pharmacology of apigenin that require resolution in future studies were also discussed.
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Keywords:
- apigenin /
- Type 2 diabetes mellitus /
- signaling pathways /
- research progress
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