Effect of protein hydrolysates from Zophobs morio on learning and memory and anti fatigue abilities of mice

To investigate the effect of different doses of Zophobs morio protein hydrolysates on learning,memory and anti fatigue abilities,KM mice were intragastric administrated 30 days' protein hydrolysates,through using Morris water- maze,climbing pole experiment and weight loading swimming test. Results showed that the incubation period of the control group without being administrated whose reaction times was 19.7% ~164.3% less than the low,middle and high dose groups was 17.2% ~62.8% longer than the other groups in the Morris watermaze,while the incubation period and reaction times of the middle dose group differed significantly from the control group( p < 0.01).At the same time,the control group 's score of weight loading swimming test was 1.9% ~16.4% lower than the other three groups and climbing pole experiment test was 6.2% ~29.8% lower in the climbing pole experiment and weight loading swimming test,and the middle dose group got the significant higher results extremely than the low and high dose group( p < 0.01).It suggested that Zophobs morio protein hydrolysates could enhance mice's learning,memory and anti fatigue abilities which was significantly associated with the dosage intragastric administrated,of which moderate dosage( 1.67 g /( kg·d)) was thought to be the most appropriate.