Auxiliary Hypoglycemic Effect of Low-GI Multigrain Cocoa Powder

NA Zhiguo; YU Shuang; HE Shuzhen; CHU Zhong

doi:10.13386/j.issn1002-0306.2022070134

Volume 44 Issue 1

Dec. 2022

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Science and Technology of Food Industry > 2023 > 44(1): 28-37. > DOI: 10.13386/j.issn1002-0306.2022070134

NA Zhiguo, YU Shuang, HE Shuzhen, et al. Auxiliary Hypoglycemic Effect of Low-GI Multigrain Cocoa Powder[J]. Science and Technology of Food Industry, 2023, 44(1): 28−37. (in Chinese with English abstract). doi: 10.13386/j.issn1002-0306.2022070134.

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Auxiliary Hypoglycemic Effect of Low-GI Multigrain Cocoa Powder

NA Zhiguo^{1, 2,},
YU Shuang²,
HE Shuzhen³,
CHU Zhong^3, ,

1.
College of Food Engineering, Harbin University of Commerce, Harbin 150028, China
2.
College of Food Engineering, East University of Heilongjiang, Harbin 150066, China
3.
Chinese Academy of Tropical Agricultural Sciences, Spice and Beverage Research Institute, Wanning 571533, China

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Received Date: July 13, 2022
Available Online: November 02, 2022

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Objective: To study the effect of low GI multigrain cocoa powder (C-MGP) on blood glucose in diabetic mice. Methods: Fifty-two male SPF mice were randomly divided into 6 groups, including normal control group, model group, metformin group, flushing powder low, medium and high-dose groups (5%, 10%, 30% C-MGP). Mice in normal control group were fed basal diet, mice in model group and metformin group were fed high-glucose and high-fat diets. Mice in low dose group (5% C-MGP), medium dose group (10% C-MGP) and high dose group (30% C-MGP) were fed high-glucose and high-fat diets containing 5% (mass fraction), 10% (mass fraction) and 30% (mass fraction) low GI mixed grain cocoa, respectively. After four weeks of high-fat diet, type Ⅱ diabetic mouse model was established by intraperitoneal injection of streptozotocin (STZ) (30 mg/kg). After successful modeling, feeding was continued for 4 weeks, basic indexes and glucose and lipid metabolism indexes were measured during the experiment in mice. Results: After high-fat diet combined with STZ induction, compared with the model group, 10% C-MGP and 30% C-MGP had significantly lower food intake and water intake (P<0.01), and significantly higher body weight (P<0.01). Compared with the model group, 30% C-MGP significantly decreased liver and kidney indexes, fasting blood glucose (FBG), glycosylated hemoglobin (GHb), fasting insulin (FINS) and insulin resistance index (HOMA-IR), and improved glucose tolerance (GT) in STZ-induced diabetic mice. Total glyceride (TG), total cholesterol (TC), low density lipid-cholesterol (LDL-C), high density lipid-cholesterol (HDL-C) and free fatty acids (FFA) levels were improved, hepatic glycogen (HG) synthesis was significantly promoted (P<0.01), and liver fat accumulation was improved. Significantly increased the content of serum glucagon like peptide-1 (GLP-1) (P<0.01), significantly decreased the level of serum lipopolysaccharide (LPS) (P<0.01). Conclusion: The 30% C-MGP had the effects of regulating glucose and lipid metabolism, and reduces diabetes symptoms on SZT induced diabetic mice, which is valuable for further development and utilization.
- coarse cereals,
- cocoa,
- hypoglycemic,
- type Ⅱ diabetes,
- mixed powder

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References

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Auxiliary Hypoglycemic Effect of Low-GI Multigrain Cocoa Powder

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